Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants.
Pathway
Activated TLR4 signalling; Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Class I MHC mediated antigen processing & presentation; Cytokine Signaling in Immune system; Downstream TCR signaling; FCERI mediated NF-kB activation; Fc epsilon receptor (FCERI) signaling; IKK complex recruitment mediated by RIP1.
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