Anti-TIMELESS (aa 1109-1207) polyclonal antibody

Species Reactivity

Human

Immunogen

TIMELESS (NP_003911, 1109 a.a. ~ 1207 a.a) partial recombinant protein with GST tag. The sequence is PELQPKVPGEQGSDEEHCKEHRAQALRALLLAHKKKAGLASPEEEDAVGKEPLKAAPKKR QLLDSDEEQEEDEGRNRAPELGAPGIQKKKRYQIEDDED

Conjugate

Alternative Names

TIMELESS; timeless circadian clock; TIM; TIM1; hTIM; protein timeless homolog; Tof1 homolog; timeless homolog; timeless circadian clock 1;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.

Pathway

Circadian rhythm pathway;