Anti-THBD monoclonal antibody, clone 252D12

Antibody Isotype

IgG1

Clone

252D12

Species Reactivity

Human

Immunogen

Recombinant protein encoding the six repeated EGF domains of human Thrombomodulin

Conjugate

Alternative Names

THBD; thrombomodulin; CD141; fetomodulin; CD141 antigen; TM; THRM; AHUS6; BDCA3; THPH12;

Entrez Gene ID

UniProt ID

Antigen Description

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Pathway

Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem;