Specifications
Species Reactivity
Rabbit; Human
Immunogen
Recombinant full length protein (Human).
Applications
Application Notes
Flow Cyt: 1μg/106 cells; IHC-P: 1 μg/ml.
Target
Alternative Names
THBD; thrombomodulin; CD141; fetomodulin; CD141 antigen; TM; THRM; AHUS6; BDCA3; THPH12;
Product Background
Antigen Description
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Pathway
Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem;
Citations
Publication ()
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COA
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