Anti-TBXAS1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

TBXAS1 (AAH14117, 1 a.a. ~ 466 a.a) full-length recombinant protein with GST tag. The sequence is MELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFL RDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTT DVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKN RDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSST GCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKL LREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPA GAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTY

Conjugate

Alternative Names

TBXAS1; thromboxane A synthase 1 (platelet); TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14; thromboxane-A synthase; TXA synthase; cytochrome P450 5A1; platelet, cytochrome P450, subfamily V; cytochrome P450, family 5, subfamily A, polypeptide 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Pathway

Arachidonic acid metabolism; Biological oxidations; Cytochrome P450 - arranged by substrate type; Eicosanoids