Anti-TBXAS1 monoclonal antibody, clone 2B23

Antibody Isotype

IgG2b

Clone

2B23

Species Reactivity

Human

Immunogen

Recombinant full length Human Thromboxane synthase produced in HEK293T cells (NP_001052).

Conjugate

Application Notes

WB: 1/2000; Flow Cyt: 1/100; ICC/IF: 1/100;

Alternative Names

TBXAS1; thromboxane A synthase 1 (platelet); thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V); thromboxane-A synthase; CYP5; CYP5A1; cytochrome P450; family 5; subfamily A; polypeptide 1; THAS; TS; TXAS; TXS; TXA synthase; cytochrome P450

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Pathway

Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Eicosanoid Synthesis, organism-specific biosystem; Eicosanoids, organism-specific biosystem; Metabolic pathways, organism-specific biosystem;