Anti-TAZ polyclonal antibody (DPABH-21226)

Rabbit anti-Human TAZ (aa 100-200) polyclonal antibody for WB Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Mouse, Human
Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human Tafazzin/ TAZ.


Application Notes
WB: 1μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
TAZ; tafazzin; EFE; BTHS; EFE2; G4.5
Entrez Gene ID
UniProt ID

Product Background

Gene summary
TAZ (Tafazzin) is a Protein Coding gene. Diseases associated with TAZ include barth syndrome and endocardial fibroelastosis. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerophosphocholine O-acyltransferase activity. This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
Antigen Description
Some isoforms may be involved in cardiolipin (CL) metabolism. Barth syndrome (BTHS) [MIM:302060]: An X-linked disease characterized by dilated cardiomyopathy with endocardial fibroelastosis, a predominantly proximal skeletal myopathy, growth retardation, neutropenia, and organic aciduria, particularly excess of 3-methylglutaconic acid. Additional features include hypertrophic cardiomyopathy, isolated left ventricular non-compaction, ventricular arrhythmia, motor delay, poor appetite, fatigue and exercise intolerance, hypoglycemia, lactic acidosis, hyperammonemia, and dramatic late catch-up growth after growth delay throughout childhood. Note=The disease is caused by mutations affecting the gene represented in this entry. Tafazzin is a protein that in humans is encoded by the TAZ gene. Tafazzin is highly expressed in cardiac and skeletal muscle. It is involved in the metabolism of cardiolipin. 0The function about TAZ antigen include 1-acylglycerophosphocholine O-acyltransferase activity.
Acyl chain remodeling of CL; Glycerophospholipid metabolism; Metabolism; Metabolism of proteins.


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Speetjens, FM; Lauwen, MM; et al. Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer. INTERNATIONAL JOURNAL OF CANCER 123:838-845(2008).
Reuschenbach, M; Kloor, M; et al. Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome. FAMILIAL CANCER 9:173-179(2010).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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