Tissue, cells or virus corresponding to Toxoplasma gondii p30.
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/4 - 1/50;
Target
Alternative Names
Major surface antigen; Surface antigen 1
Product Background
Antigen Description
Toxoplasma gondii p30 is the immunodominant surface antigen of Toxoplasma gondii. Toxoplasma gondii is an obligate intracellular protozoan that belongs to the class Sporozoa, and the order Eucoccidia. The parasite has an extremely wide host range and is also nonspecific with respect to the kind of cell type it can enter, making it an interesting model to study invasion. Although toxoplasmosis in healthy adults is generally asymptomatic, it produces severe disease in neonates and immunocompromised people, being the cause of death in many AIDS patients. P30 is the major surface antigen of T. gondii. It is a very abundant protein, conserved in most strains, and present both in the vesicular network of the parasitophorous vacuole and on the surface of the parasite. It is very immunogenic, eliciting high titers of antibodies in infected individuals. The gene coding for P30 has been cloned and completely sequenced: the deduced amino acid sequence shows a putative signal sequence at the N terminus, consistent with localization of P30 on the parasite's surface, as well as a short hydrophobic stretch at the C terminus.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Radke, JR; Gubbels, MJ; et al. Identification of a sporozoite-specific member of the Toxoplasma SAG superfamily via genetic complementation. MOLECULAR MICROBIOLOGY 52:93-105(2004).
de Azevedo, SS; Pena, HFD; et al. Prevalence of anti-Toxoplasma gondii and anti-Neospora caninum antibodies in swine from Northeastern Brazil. REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA 19:80-84(2010).
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COA
Certificate of Analysis
