Product Overview
Active T. gondii Toxoplasma gondii p30 protein fragment
Bio-activity
Active T. gondii Toxoplasma gondii p30 protein fragment is immunoreactive with sera of Toxoplasma gondii-infected individuals.
Purity
> 95 % by SDS-PAGE.This antigen was purified by a proprietary chromatographic technique.
Buffer
20mM PB,150mM NaCl, pH 7.5
Storage
2-8°C short term, -20°C long term
Introduction
Toxoplasma gondii is an obligate, intracellular, parasitic protozoan that causes the disease toxoplasmosis.
Antigen Description
Toxoplasma gondii p30 is the immunodominant surface antigen of Toxoplasma gondii. Toxoplasma gondii is an obligate intracellular protozoan that belongs to the class Sporozoa, and the order Eucoccidia. The parasite has an extremely wide host range and is also nonspecific with respect to the kind of cell type it can enter, making it an interesting model to study invasion. Although toxoplasmosis in healthy adults is generally asymptomatic, it produces severe disease in neonates and immunocompromised people, being the cause of death in many AIDS patients. P30 is the major surface antigen of T. gondii. It is a very abundant protein, conserved in most strains, and present both in the vesicular network of the parasitophorous vacuole and on the surface of the parasite. It is very immunogenic, eliciting high titers of antibodies in infected individuals. The gene coding for P30 has been cloned and completely sequenced: the deduced amino acid sequence shows a putative signal sequence at the N terminus, consistent with localization of P30 on the parasite's surface, as well as a short hydrophobic stretch at the C terminus.
Keywords
Major surface antigen p30; p30; SAG1; SAG1 protein; T. gondii p30; Toxoplasma gondii p30
Citations
Publication ()
Have you cited DAG-P2776 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
