Recombinant fragment within Human Smad4 aa 14-227. The exact sequence is proprietary. (With tag; BC002379).Sequence: DACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITT NGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVK YCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQ
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/200 - 1/500.
Target
Alternative Names
SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted
Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor.
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