Anti-SMAD4 (mutation R361H) Monoclonal Antibody, clone XH114

Clone

XH114

Species Reactivity

Human

Immunogen

A synthetic peptide from the internal region of SMAD4 which includes the mutation of R361H, human origin.

Conjugate

Application Notes

ELISA: 1:1000-1:5000
WB: 1:100-1:1000
IHC: 1:50-1:200

Entrez Gene ID

Antigen Description

SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-β signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiploid colorectal cancer and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominantdisease juvenile polyposis syndrome (JPS).

Pathway

ALK1 signaling events; Activin signaling; Adherens junction;