Anti-SYNCRIP monoclonal antibody (DCABH-99)

Mouse anti-Human SYNCRIP monoclonal antibody for ICC/IF, FC, ELISA, WB, IP Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
J9F5
Species Reactivity
Mouse, Human, Xenopus laevis
Immunogen
Recombinant untagged hnRNP-Q protein (human).
Conjugate
Unconjugated

Applications


Application Notes
Flow Cyt: 1μg/106 cells.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SYNCRIP; synaptotagmin binding, cytoplasmic RNA interacting protein; heterogeneous nuclear ribonucleoprotein Q; dJ3J17.2; GRY RBP; hnRNP Q
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SYNCRIP (Synaptotagmin Binding Cytoplasmic RNA Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPR. This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20.
Antigen Description
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. Synaptotagmin binding, cytoplasmic RNA interacting protein, also known as Heterogeneous nuclear ribonucleoprotein Q is a protein that in humans is encoded by the SYNCRIP gene. 0The function about SYNCRIP antigen include RNA binding; nucleotide binding; protein binding.

Citations


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References


Wang, LY; Jeng, KS; et al. Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5 ' Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome. JOURNAL OF VIROLOGY 85:7954-7964(2011).
Gorla, L; Cantu, M; et al. RET oncoproteins induce tyrosine phosphorylation changes of proteins involved in RNA metabolism. CELLULAR SIGNALLING 18:2272-2282(2006).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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