Anti-SYNCRIP (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human hnRNP Q aa 1-410. Isoform 5Sequence: MEDHLQIPFIQIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLN RGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPK SKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGSCFLEYEDHKTAAQA RRRLMSGKVKVWGNVGTVEWAD

Conjugate

Application Notes

WB: 1/500 - 1/1000;

Alternative Names

SYNCRIP; synaptotagmin binding, cytoplasmic RNA interacting protein; PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q; heterogeneous nuclear ribonucleoprotein Q; NS1-associated protein 1; glycine- and tyrosine-rich RNA-binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.