Anti-STXBP1 monoclonal antibody, clone FQS5961

Antibody Isotype

IgG

Clone

FQS5961

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide corresponding to residues in Human Munc18.

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/250 - 1/500; ICC: 1/100 - 1/250;

Alternative Names

STXBP1; syntaxin binding protein 1; syntaxin-binding protein 1; hUNC18; MUNC18 1; rbSec1; UNC18; N-Sec1; unc-18A; unc18-1; neuronal SEC1; protein unc-18 homolog 1; protein unc-18 homolog A; P67; NSEC1; RBSEC1; MUNC18-1; FLJ37475;

Entrez Gene ID

UniProt ID

Antigen Description

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Pathway

Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem; Dopamine Neurotransmitter Release Cycle, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Effects of Botulinum toxin, organism-specific biosystem; GABA synthesis, release, reuptake and degradation, organism-specific biosystem; Glutamate Neurotransmitter Release Cycle, organism-specific biosystem; Insulin Signaling, organism-specific biosystem;