Anti-STXBP1 monoclonal antibody (CAB-4783MH)

Mouse anti-STXBP1 monoclonal antibody for ELISA, WB, IHC Datasheet

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Host Species
Antibody Isotype
IgG2a Kappa
Species Reactivity
STXBP1 (NP_003156, 74 a.a. - 169 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
STXBP1; syntaxin binding protein 1; syntaxin-binding protein 1; hUNC18; MUNC18 1; rbSec1
Entrez Gene ID
UniProt ID

Product Background

Gene summary
STXBP1 (Syntaxin Binding Protein 1) is a Protein Coding gene. Diseases associated with STXBP1 include epileptic encephalopathy, early infantile, 4 and ohtahara syndrome. Among its related pathways are Metabolism and Neurotransmitter Release Cycle. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is STXBP3. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
Antigen Description
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Epileptic encephalopathy, early infantile, 4 (EIEE4) [MIM:612164]: A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Affected individuals have neonatal or infantile onset of seizures, profound mental retardation, and MRI evidence of brain hypomyelination. Note=The disease is caused by mutations affecting the gene represented in this entry. Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene. 0The function about STXBP1 antigen include SNARE binding; identical protein binding; syntaxin-1 binding; syntaxin-2 binding.
Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem; Dopamine Neurotransmitter Release Cycle, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Effects of Botulinum toxin, organism-specific biosystem; GABA synthesis, release, reuptake and degradation, organism-specific biosystem; Glutamate Neurotransmitter Release Cycle, organism-specific biosystem; Insulin Signaling, organism-specific biosystem.


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Backovic, M; DuBois, RM; et al. Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:22635-22640(2010).
Wong, FK; Li, Q; et al. Synaptic vesicle capture by CaV2.2 calcium channels. FRONTIERS IN CELLULAR NEUROSCIENCE 7:-(2013).

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