Specifications
Immunogen
Synthetic peptide: C-DEAQNIKNFKSQR, corresponding to internal sequence amino acids 746-758 of Human SRCAP (NP_006653.2).
Target
Alternative Names
SRCAP; Snf2-related CREBBP activator protein; EAF1; FLHS; SWR1; DOMO1; helicase SRCAP; domino homolog 2; Snf2-related CBP activator protein; Swi2/Snf2-related ATPase homolog, domino homolog 1;
Product Background
Antigen Description
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription (from SwissProt).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Deal, RB; Topp, CN; et al. Repression of flowering in Arabidopsis requires activation of FLOWERING LOCUS C expression by the histone variant H2A.Z. PLANT CELL 19:74-83(2007).
Okazaki, N; Ikeda, S; et al. The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS. JOURNAL OF MOLECULAR BIOLOGY 382:257-265(2008).
COA
Certificate of Analysis
