Synthetic peptide corresponding to a region within internal amino acids 40-89 (PCHPKVPEPC HPKVPEPCQP KVPEPCQPKV PEPCPSTVTP APAQQKTKQK) of Human SPRR1a (NP_005978).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
SPRR1A; small proline-rich protein 1A; SPRK; cornifin-A; SPR-IA; cornifin A; 19 kDa pancornulin; small proline-rich protein IA;
The ability of neurons to regenerate an axon after injury is determined by both the surrounding environment and factors intrinsic to the damaged neuron. Neuronal SPRR1A is likely a significant contributor to successful nerve regeneration. The small proline-rich repeat protein 1A (SPRR1A) is not detectable in uninjured neurons but is induced by >60-fold after peripheral axonal damage being localized to injured neurons and axons. SPRR1A is one of a group of epithelial differentiation genes, including s100c and p21/waf, that are cocurrently induced in neurons by axotomy. Overexpressed SPRR1A colocalizes with F-actin in membrane ruffles and augments axonal outgrowth on a range of substrates. In axotomized sensory neurons, reduction of SPRR1A function restricts axonal outgrowth.
Citations
Publication ()
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