SPRR1A (small proline-rich protein 1A) is a protein-coding gene. Diseases associated with SPRR1A include spinal cord injury, and esophageal squamous cell carcinoma. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is SPRR1B. Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
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