Anti-SNAI1 monoclonal antibody, clone 7E3

Antibody Isotype

IgG1

Clone

7E3

Species Reactivity

Human

Immunogen

Purified recombinant fragment of Human SNAIL expressed in E.coli.

Conjugate

Application Notes

WB: 1/500 - 1/2000; ELISA: 1/10000;

Alternative Names

SNAI1; snail homolog 1 (Drosophila); snail 1 (drosophila homolog), zinc finger protein; zinc finger protein SNAI1; SLUGH2; SNA; SNAH; SNAIL; SNAIL1; protein sna; snail 1 homolog; protein snail homolog 1; snail 1 zinc finger protein; snail 1, zinc finger p

Entrez Gene ID

UniProt ID

Antigen Description

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Pathway

Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem; Validated targets of C-MYC transcriptional activation, organism-specific biosystem;