Magic™ Anti-SNAI1 (Phospho S246) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to Human SNAIL (phospho S246) conjugated to Keyhole Limpet Haemocyanin (KLH). Peptide sequence around phosphorylation site of Serine 246 (T-F-S(p)-R-M) derived from Human SNAIL. NCBI Protein#: NP_005976.2.Database link: O95

Conjugate

Application Notes

WB: 1/500 - 1/1000

Alternative Names

SNAI1; snail family zinc finger 1; SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1; zinc finger protein SNAI1; protein sna; snail 1 homolog; snail homolog 1; protein snail homolog 1; snail 1 zinc finger protein; snail 1, zinc finger protein;

Entrez Gene ID

UniProt ID

Antigen Description

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Pathway

Adherens junction; Neural Crest Differentiation; Validated targets of C-MYC transcriptional activation;