Anti-SMYD2 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human KMT3C/ SMYD2 aa 1-433. (NP_064582.1)Sequence: MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGN HCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENW NPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQ SDIAALHHFYSKH

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

SMYD2; SET and MYND domain containing 2; KMT3C; HSKM-B; ZMYND14; N-lysine methyltransferase SMYD2; lysine N-methyltransferase 3C; histone methyltransferase SMYD2; zinc finger, MYND domain containing 14; SET and MYND domain-containing protein 2;

Entrez Gene ID

UniProt ID

Antigen Description

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 Lys-4 (H3K4me) and dimethylates histone H3 Lys-36 (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates Lys-370 of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates Lys-860 of RB1/RB.

Pathway

p53 pathway;