Specifications
Immunogen
Tissue, cells or virus corresponding to Human SLAM/ CD150. Human SLAM/ CD150-transfected 300.19 cells.Database link: Q13291
Applications
Application Notes
Flow Cyt Use 10μl for 106 cells.
Target
Alternative Names
SLAMF1; signaling lymphocytic activation molecule family member 1; signaling lymphocytic activation molecule , SLAM; signaling lymphocytic activation molecule; CD150; IPO-3; SLAM; CDw150;
Product Background
Antigen Description
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Pathway
Measles, organism-specific biosystem; Measles, conserved biosystem;
Citations
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Richter, GHS; Mollweide, A; et al. CD25 Blockade protects T Cells from Activation-induced Cell Death (AICD) via Maintenance of TOSO Expression. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 70:206-215(2009).
Keszei, M; Latchman, YE; et al. Auto-antibody production and glomerulonephritis incongenic Slamf1(-/-) and Slamf2(-/-) [B6.129] but not in Slamf1(-/-) and Slamf2(-/-) [BALB/c.129] mice (vol 23, pg 149, 2011). INTERNATIONAL IMMUNOLOGY 23:463-463(2011).
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