Synthetic peptide: C-QRRHAKTNSHSSALH (with a Cysteine residue linker), corresponding to N terminal amino acids 174-188 of Human CLLD8/SETDB2 accoring to Q96T68. (NP_114121.2; NP_001153780.1.)
Conjugate
Unconjugated
Applications
Application Notes
WB: 0.1 - 0.3μg/ml;
Target
Alternative Names
SETDB2; SET domain, bifurcated 2; CLLD8; CLLL8; KMT1F; C13orf4; histone-lysine N-methyltransferase SETDB2; lysine N-methyltransferase 1F; chronic lymphocytic leukemia deletion region 8; chronic lymphocytic leukemia deletion region gene 8 protein;
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates Lys-9 of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Pathway
Lysine degradation.
Citations
Publication ()
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