Anti-SELE monoclonal antibody

The Sele river plain is located along the western Tyrrhenian margin of the southern Apennine Chain and is confined seaward by a straight sandy coast formed during the Last Interglacial and the Holocene. The coastal plain is characterised by beach-dune ridges which interfinger landwards with lagoon and fluvio-palustrine deposits. This belt, which progressively grew up, represents the evolution of a barrier-lagoon system alternatively shifting landwards and seawards. The knowledge on the Holocene evolution of the Sele river coastal plain, along the coast of the Poseidonia-Paestum archaeological area, was improved by the drilling of two new cores and the collection of several archaeo-tephro-stratigraphic data. The area experienced the Holocene marine transgression which cut high cliffs in the travertine deposits. During the second half of the Holocene, the shoreline shifted seawards and a lagoon-beach bar system (Fossa Lupata-Laura) formed. The archaeological remains (VI cent. b.c.) and the Agnano Monte Spina tephra layer (4.1 ky BP) constrain chronologically this morpho-sedimentary system. After the VI cent. b.c., and mostly after the deposition of the 79 a.d. tephra layer, the shoreline shifted seawards and an additional beach ridge formed, while the flat area at the back (Fossa Lupata) was rapidly aggraded and dried up.

The spectral third-generation wind-wave model WAVEWATCH III, operational since January 2005 at the Department of Applied Sciences of the Parthenope University, was adopted for simulating wave propagation and risk evaluation in the Gulf of Naples. The model was coupled with PSU/NCAR mesoscale model (MM5), which gives wind forcing at I-h intervals. The model was implemented using a four-nested grid configuration covering the Mediterranean Sea toward the Gulf of Naples. Simulated results were compared with data recorded in 2000 offshore of the Gulf of Naples and with wind and wave data collected by APAT offshore of the mouth of river Sele in the Gulf of Salerno. Maps of coastal vulnerability, damage and risk were obtained taking into account the wave vulnerability and the potential damage to people and structures in case of coastal inundation. The obtained results are also used to classify the coastal zones of the Naples Province on the basis of the risk evaluation.