Anti-SAP18 (aa 1-100) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human SAP18.

Conjugate

Application Notes

ICC/IF: 1 μg/ml. IHC-P: 1/650. IP: 1.6 μg/ml; WB: 1 μg/ml.

Alternative Names

SAP18; Sin3A-associated protein, 18kDa; sin3A associated protein, 18kDa; histone deacetylase complex subunit SAP18; 2HOR0202; MGC27131; SAP18p; sin3-associated polypeptide p18; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; cell grow

Entrez Gene ID

UniProt ID

Antigen Description

Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.

Pathway

Exon junction complex (EJC); Hedgehog Signaling Pathway; Hedgehog signaling events mediated by Gli proteins; RNA transport; Regulation of Telomerase; Regulation of nuclear SMAD2/3 signaling;