Anti-SAP18 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SAP18 is used for rabbit immunization.

Conjugate

Alternative Names

SAP18; Sin3A-associated protein, 18kDa; sin3A associated protein, 18kDa; histone deacetylase complex subunit SAP18; 2HOR0202; MGC27131; SAP18p; sin3-associated polypeptide p18; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; cell grow

Entrez Gene ID

UniProt ID

Antigen Description

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.

Pathway

Exon junction complex (EJC), organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem; Regulation of Telomerase, organism-specific biosystem; Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem;