Anti-RUNX1 (aa 252-301) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide corresponding to a region within internal sequence amino acids 252-301 (SLNHSTAFNP QPQSQMQDTR QIQPSPPWSY DQSYQYLGSI ASPSVHPATP) of Human RUNX1/ AML1 (NP_001745).

Conjugate

Application Notes

ICC/IF: 1 μg/ml; WB: 1 μg/ml;

Alternative Names

RUNX1; runt-related transcription factor 1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1; CBF-alpha-2; PEA2-alpha B; PEBP2-alpha B; oncogene AML-1; AML1-EVI-1 fusion protein; acute myeloid leukemia 1 protein; SL3-3 enhancer factor 1 alpha B subunit; SL

Entrez Gene ID

UniProt ID

Antigen Description

CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.

Pathway

Acute myeloid leukemia; Chronic myeloid leukemia; Pathways in cancer; Transcriptional misregulation in cancer