Anti-RUNX1T1 (aa 416-525) polyclonal antibody

Species Reactivity

Human

Immunogen

RUNX1T1 (NP_004340, 416 a.a. ~ 525 a.a) partial recombinant protein with GST tag. The sequence is EEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDAL AVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICG

Conjugate

Alternative Names

RUNX1T1; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); CDR; ETO; MTG8; AML1T1; ZMYND2; CBFA2T1; protein CBFA2T1; eight twenty one protein; CBFA2T1 isoform r1t1-7a47; CBFA2T1 isoform r1t1-7a48; CBFA2T1 isoform r1t1-7a49; CBFA2

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5-region of the runt-related transcription factor 1 gene fused to the 3-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Pathway

Acute myeloid leukemia; Transcriptional misregulation in cancer;