Anti-RRM1 (aa 644-753) polyclonal antibody

Species Reactivity

Human

Immunogen

RRM1 (NP_001024, 644 a.a. ~ 753 a.a) partial recombinant protein with GST tag. The sequence is DLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFID QSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLN

Conjugate

Alternative Names

RRM1; ribonucleotide reductase M1; R1; RR1; RIR1; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase, R1 subunit; ribonucleotide reductase M1 polypeptide; ribonucleoside-diphosphate reductase subunit M1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Pathway

E2F transcription factor network; Glutathione metabolism; Integrated Pancreatic Cancer Pathway; Metabolism of nucleotides