Anti-RPS27 monoclonal antibody, clone 8F4

Antibody Isotype

IgG1

Clone

8F4

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human RPS27.

Conjugate

Application Notes

ELISA (1:10000); Immunofluorescence (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Alternative Names

RPS27; ribosomal protein S27; ribosomal protein S27 (metallopanstimulin 1); 40S ribosomal protein S27; metallopanstimulin 1; MPS 1; MPS1; S27; metallopan-stimulin 1; MPS-1;

Entrez Gene ID

UniProt ID

Antigen Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Pathway

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem; DNA Replication, organism-specific biosystem; Disease, organism-specific biosystem;