RNF8 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RNF8.
Conjugate
Unconjugated
Target
Alternative Names
RNF8; ring finger protein 8, E3 ubiquitin protein ligase; hRNF8; E3 ubiquitin-protein ligase RNF8; C3HC4-type zinc finger protein; ring finger protein (C3HC4 type) 8; UBC13/UEV-interacting ring finger protein
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Citations
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