Anti-RICTOR (aa 250-350) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human RICTOR.

Conjugate

Application Notes

WB: 1 μg/ml; ICC/IF: 5 μg/ml.

Alternative Names

RICTOR; RPTOR independent companion of MTOR, complex 2; rapamycin-insensitive companion of mTOR; AVO3; KIAA1999; MGC39830; PIA; pianissimo; rapamycin insensitive companion of mTOR; hAVO3; AVO3 homolog; TORC2-specific protein AVO3; mAVO3; DKFZp686B11164;

Entrez Gene ID

UniProt ID

Antigen Description

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.

Pathway

Adaptive Immune System; CD28 co-stimulation; CD28 dependent PI3K/Akt signaling; CXCR3-mediated signaling events; CXCR4-mediated signaling events; Class I PI3K signaling events mediated by Akt; Costimulation by the CD28 family