Anti-RICTOR Monoclonal antibody, clone 2H4-Q3D0

Antibody Isotype

IgG1

Clone

2H4-Q3D0

Species Reactivity

Human

Immunogen

Synthetic peptide within Human RICTOR aa 1650-1708 (C terminal). The exact sequence is proprietary.Sequence: I CLYSEVSHLL SHCTFRLPCR RFIQELFQDV QFLQMHEEAE AVLATPPKQP IVDTSAES Database link: Q6R327

Conjugate

Application Notes

ICC: 1/500 - 1/2000; IHC-P: 1/100 - 1/500; WB: 1/1000 - 1/10000; IP: 2-5 μg/mg.

Alternative Names

RICTOR; RPTOR independent companion of MTOR, complex 2; rapamycin-insensitive companion of mTOR; AVO3; KIAA1999; MGC39830; PIA; pianissimo; rapamycin insensitive companion of mTOR; hAVO3; AVO3 homolog; TORC2-specific protein AVO3; mAVO3; DKFZp686B11164;

Entrez Gene ID

UniProt ID

Antigen Description

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.

Pathway

Adaptive Immune System, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; CXCR3-mediated signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Class I PI3K signaling events mediated by Akt, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem;