Synthetic peptide, corresponding to 14 amino acids at the N terminus of Human RHEB.
Conjugate
Unconjugated
Applications
Application Notes
WB: Use at a concentration of 2 - 4 μg/ml. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa). Post-translationally modified Rheb is sometimes observed at higher molecular weight.
Target
Alternative Names
RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2; RHEB2; GTP-binding protein Rheb; Ras homolog enriched in brain 2; RHEB2; MGC111559;
Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.
Pathway
Energy dependent regulation of mTOR by LKB1-AMPK; IRS-mediated signalling; IRS-related events; Insulin Signaling; Insulin receptor signalling cascade; Insulin signaling pathway;
Citations
Publication ()
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COA
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