This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Pathway
AMPK signaling pathway; Energy dependent regulation of mTOR by LKB1-AMPK; FSH signaling pathway; IGF1R signaling cascade; IRS-mediated signalling; IRS-related events; IRS-related events triggered by IGF1R; Insulin Signaling
Citations
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