RHBDF1 (rhomboid 5 homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with RHBDF1 include fgfr-related craniosynostosis syndromes, and craniosynostosis, syndromic. GO annotations related to this gene include growth factor binding and serine-type endopeptidase activity. An important paralog of this gene is RHBDF2. Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.
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