Anti-RFXANK monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human RFXANK is used for rabbit immunization.

Conjugate

Alternative Names

RFXANK; regulatory factor X-associated ankyrin-containing protein; DNA-binding protein RFXANK; ANKRA1; ankyrin repeat containing regulatory factor X associated protein; BLS; DNA binding protein RFXANK; F14150_1; MGC138628; regulatory factor X subunit B; R

Entrez Gene ID

UniProt ID

Antigen Description

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.

Pathway

Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; Tuberculosis, organism-specific biosystem;