Anti-RBM38 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to amino acids 1-239 of Human RBM38. (NP_05965.2).

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

RBM38; RNA binding motif protein 38; RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2; RNA-binding protein 38; ssDNA-binding protein SEB4; CLL-associated antigen KW-5; RNA-binding region-containing protein 1; RNA-binding region (RNP1, RRM) containing 1;

Entrez Gene ID

UniProt ID

Antigen Description

RNA-binding protein that specifically bind the 3-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.