Anti-RBM38 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human RBM38 is used for rabbit immunization.

Conjugate

Alternative Names

RBM38; RNA binding motif protein 38; RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2; RNA-binding protein 38; ssDNA-binding protein SEB4; CLL-associated antigen KW-5; RNA-binding region-containing protein 1; RNA-binding region (RNP1, RRM) containing 1;

Entrez Gene ID

UniProt ID

Antigen Description

RBM38 (RNA binding motif protein 38) is a protein-coding gene. Diseases associated with RBM38 include esophageal adenocarcinoma, and chronic lymphocytic leukemia. GO annotations related to this gene include mRNA 3'-UTR binding and nucleotide binding. An important paralog of this gene is RBM24. RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.