Synthetic peptide within Mouse NORE1 aa 351-400 (C terminal). The exact sequence is proprietary.Sequence: SFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIHQLQKKYNKFRQK Database link: NP_061220
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml;
Target
Alternative Names
RASSF5; Ras association (RalGDS/AF-6) domain family member 5; Rapl; Maxp1; Nore1; Nore1A; Nore1B; AU042887; 1300019G20Rik; ras association domain-containing protein 5; new ras effector 1; Rap1-binding protein; novel ras effector 1; Ras association (RalGDS
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Liu, GG; Shi, ZB; et al. Structure of MST2 SARAH domain provides insights into its interaction with RAPL. JOURNAL OF STRUCTURAL BIOLOGY 185:366-374(2014).
Steinmann, K; Sandner, A; et al. Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma. ONCOLOGY REPORTS 22:1519-1526(2009).
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COA
Certificate of Analysis
