Anti-RASSF5 monoclonal antibody, clone 2B22

Antibody Isotype

IgG1

Clone

2B22

Species Reactivity

Human

Immunogen

Recombinant full length Human NORE1 produced in HEK293T cells (NP_872606).

Conjugate

Application Notes

WB: 1/500;

Alternative Names

RASSF5; Ras association (RalGDS/AF-6) domain family member 5; ras association domain-containing protein 5; Maxp1; NORE1; RAPL; new ras effector 1; Rap1-binding protein; novel Ras effector 1; tumor suppressor RASSF3; Ras effector-like protein; Ras associat

Entrez Gene ID

UniProt ID

Antigen Description

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.

Pathway

Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem; TCR signaling in naive CD4+ T cells, organism-specific biosystem; TCR signaling in naive CD8+ T cells, organism-specific biosystem;