Rabbit Anti-Human RASA4 (C-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Fusion protein corresponding to residues near the C terminal of human RAS p21 protein activator 4

Conjugate

Application Notes

IHC: 1:10-1:50

General Notes

This product (Catalog No. DPABH-03353) is a rabbit-derived polyclonal antibody raised against human RASA4. It has been affinity purified by Protein A. This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
DPABH-03353 is suitable for use in IHC (1:10–1:50) application.
DPABH-03353 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

GAPL; CAPRI

Entrez Gene ID

UniProt ID