Anti-RAP1A + RAP1B monoclonal antibody, clone FQS25926(C)

Antibody Isotype

IgG

Clone

FQS25926(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human RAP1A + RAP1B aa 100 to the C-terminus. The exact sequence is proprietary.

Conjugate

Application Notes

Flow Cyt: 1/30; IP: 1/50; WB: 1/10000 - 1/50000.

Alternative Names

RAP1A; RAP1A, member of RAS oncogene family; ras-related protein Rap-1A; KREV 1; SMGP21; C21KG; G-22K; RAS-related protein RAP1A; Ras-related protein Krev-1; GTP-binding protein smg p21A; RAP1; KREV1; KREV-1;

Entrez Gene ID

UniProt ID

Antigen Description

RAP1A and RAP1B belong to a family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Human RAP1B is 95% identical to RAP1A. RAP1A and B are proposed to regulate Ras-mediated signalling and may also be involved in the regulation of integrin-mediated cell adhesion, although the mechanism of regulation is not known.

Pathway

ARMS-mediated activation, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; Focal Adhesion, organism-specific biosystem.