Anti-RAP1A (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

RAP1A (AAH14086.1, 1 a.a. ~ 184 a.a) full-length recombinant protein with GST tag. The sequence is MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS CLLL

Conjugate

Alternative Names

RAP1A; RAP1A, member of RAS oncogene family; RAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21; ras-related protein Rap-1A; Ras-related protein Krev-1; GTP-binding protein smg p21A;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants.

Pathway

ARMS-mediated activation; BDNF signaling pathway; Chemokine signaling pathway; EPO signaling pathway