Anti-RALB (internal region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Human RALB (internal sequence).Database link: P11234

Conjugate

Application Notes

WB: 1/100 - 1/2000; IHC-P: 1/100 - 1/1000.

Alternative Names

RALB; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein); ras-related protein Ral-B; RAS-like protein B; GTP binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.

Pathway

CXCR4-mediated signaling events; EGFR1 Signaling Pathway; NGF signalling via TRKA from the plasma membrane; Pancreatic cancer; Pathways in cancer; Signal Transduction;