Anti-RALB monoclonal antibody, clone 3D5

Antibody Isotype

IgG1

Clone

3D5

Species Reactivity

Mouse; Rat; Dog; Human; Monkey

Immunogen

Recombinant full length Human RALB (amino acids 1-206) produced in HEK293T cells (NP_002872).

Conjugate

Application Notes

WB: 1/200 - 1/4000; IHC-P: 1/150; ICC/IF: 1/100;

Alternative Names

RALB; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein); ras-related protein Ral-B; RAS-like protein B; GTP binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.

Pathway

CXCR4-mediated signaling events, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; Pancreatic cancer, organism-specific biosystem; Pancreatic cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem; Signal Transduction, organism-specific biosystem;