Anti-PIV type 3 Monoclonal antibody, Clone 2367 (C276)

Microfluidic platforms have increasingly been explored for in vitro blood diagnostics and for studying complex microvascular processes. The perfusion of blood in such devices is typically achieved through pressure-driven setups. Surface tension driven blood flow provides an alternative flow delivery option, and various studies in the literature have examined the behavior of blood flow in such fluidic devices. In such flows, the influence of red blood cell (RBC) aggregation, the phenomenon majorly responsible for the non-Newtonian nature of blood, requires particular attention. In the present work, we examine differences in the surface tension driven flow of aggregating and non-aggregating RBC and Newtonian suspensions, in a rectangular microchannel. The velocity fields were obtained using micro-PIV techniques. The analytical solution for blood velocity in the channel is developed utilizing the power law model for blood viscosity. The results showed that RBC aggregation has an impact at the late stages of the flow, observed mainly in the bluntness of the velocity profiles. At the initial stages of the flow, the shearing conditions are found moderately elevated, preventing intense RBC aggregate formation. As the flow decelerates in the channel, RBC aggregation increases, affecting the flow characteristics.

Particle trapping and deposition around an obstacle occur in many natural and industrial situations and in particular in the nuclear industry. In the steam generator of a nuclear power plant, the progressive obstruction of the flow due to particle deposition reduces the efficiency and can induce tube cracking leading to breaking and damage. The steam generator then loses its role as a safety barrier of the nuclear power plant. From a fundamental standpoint, dilute and concentrated particulate flows have received a growing attention in the last decade. In this study, we investigate the transport of solid particles around obstacles in a confined flow. Experiments were performed in a simplified configuration by considering a laminar flow in a vertical tube. An obstacle was inserted at the middle height of the tube and neutrally-buoyant particles were injected at different locations along the tube. We have investigated first the trajectories of individual particles using particle tracking (PT). Then, the particle trajectories were modeled by using the Boussinesq-Basset-Oseen equation with a flow velocity field either measured using particle image velocimetry (PIV) or calculated by theCode_Saturnesoftware in order to account for the three-dimensional (3D) character of the obstacle wake. This paper presents a comparison between the experimental observations and the predictions of the modeling for an obstacle consisting of a rectangular step at a Reynolds number of approximate to 100 and evidences the importance of accounting for the 3D complex nature of the flow.