Specifications
Immunogen
Synthetic peptide, corresponding to residues in Human TMS1 (UniProt: Q9ULZ3).
Applications
Application Notes
WB: 1/1000 - 1/10000; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100;
Target
Alternative Names
PYCARD; PYD and CARD domain containing; apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; TMS 1; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; TMS; TMS1; TMS-1; MGC10332;
Product Background
Antigen Description
Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Pathway
Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Immune System, organism-specific biosystem; Inflammasomes, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem;
Citations
Publication ()
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COA
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