Anti-PYCARD monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PYCARD is used for rabbit immunization.

Conjugate

Alternative Names

PYCARD; PYD and CARD domain containing; apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; TMS 1; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; TMS; TMS1; TMS-1; MGC10332;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Pathway

Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Immune System, organism-specific biosystem; Inflammasomes, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem;