Human PYCARD blocking peptide

Product Overview

ASC / TMS 1 ( C - term ) peptide ( human )

Target

TMS1

Nature

Synthetic

Tag/Conjugate

Unconjugated

Concentration

0.2 mg/ml

Buffer

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Preservative

0.02% Sodium Azide

Storage

Upon Receipt - Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.

Entrez Gene ID

Antigen Description

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function

Pyrin domain binding; cysteine-type endopeptidase activator activity involved in apoptotic process; ion channel binding; protease binding; protein binding; protein homodimerization activity;

Synonyms

PYCARD; PYD and CARD domain containing; ASC; TMS; TMS1; CARD5; TMS-1; apoptosis-associated speck-like protein containing a CARD; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5;